Antioxidant / Male Fertility Effect: Study on the antioxidant effect of Kigelia
fruit extract on normal rats showed a non-dose dependent elevation in
testicular catalase, a significant decline in malondialdehyde and an
up-regulation of glutathione. Results offer scientific basis for the use of Kigelia
Africana fruit extract in the treat of male infertility.
Antibacterial: Study confirmed the antibacterial activity of K. Africana fruits and stem bark.
Antineoplastic: (1) Study of crude dichlormethane extracts of
stem bark and fruit showed cytotoxic activity in vitro against cultured melanoma
and other cancer cell lines. Major components were norviburtinal and
ß-sitosterol. (2) Kigelia also contains lapachol which has been found effect in
the treatment of solar keratosis, skin cancer and kaposis sarcoma.
Analgesic/ Anti-Inflammatory: Study of stem bark showed significant analgesic
and anti-inflammatory effect most likely via inhibition of prostaglandin
Antimalarial: Study isolated four naphthoquinoids from the root bark of the
plant. Results showed good anti-plasmodial activity against
chloroquine-resistant and chloroquine-sensitive strains of Plasmodium
CNS Stimulant: Study of ethanolic stem bark extract in mice showed a CNS stimulant
effect as shown by a dose-dependent reduction of the duration of
barbiturate-induced sleeping time. It suggests a potential for possible use in
conditions associated with dizziness, drowsiness and sedation.
Antiprotozoal: Study of stem bark and root bark extracts
showed pronounced activity against both Trypanosoma brucei and T. b.
rhodesiense bloodstream forms. A butanol stem extract showed in vitro
Antidiarrheal: Study of an aqueous leaf extract of K. Africana showed
antidiarrheal activity with reduced fecal output and protection from castor
oil-induced diarrhea in extract-treated animals.
Study yields steroidal saponins and two flavonoids (luteolin and quercitin).
Reports claim the fruit extract is useful in developing the bust and
reinforcing the strength and stability of breast collagen fibers. (2)
Dermal preparations claim to remove sunspots ("solar keratosis")
especially in the face and hands. Claims are also made for reduction of wrinkle
depth and promotion of tone elasticity, reduction of skin blemishes.
Verminoside / Anti-Inflammatory: Study of fruit extract yielded verminoside. In
vitro assays showed it to have significant anti-inflammatory effects,
inhibiting both iNOS expression and NO release.
Anticonvulsant: Study of Kigelia pinnata showed an anti-seizure
effect which may be due in part to linoleic acid, cinnamic acid, and/or
flavonoid compounds in the extracts. (6)
Antidiarrheal / Spasmolytic: Study of E senegalensis and Kigelia Africana
showed significant reduction in the frequency of diarrhea stools and
spontaneous propulsive movement of isolated rabbit jejunum. The spasmolytic
effect may explain its use folkloric use in chronic abdominal pain and pains
associated with diarrhea. (7)
Antiproliferative / Spasmolytic: Study
of seed oils of K. Africana, Mimusops zeyheri and Ximenia caffra on cell
proliferation in culture showed suppression of of human colon adenoCA (Caco-2)
and human embryonic kidney cells (HEK-293). Results suggest a potential
antiproliferative effect of the seed oils on the cell lines. (11)
/ Cisplat: in study of a fruit extract of K. Africana (KAFE) in
cisplatin treated male rats. While KAFE may protect against cisplatin-induced
testicular damage, the study shows pretreatment may offer a better option in
reducing cisplatin-induced damage to the testis in a mechanism believed to be
free-radical mediated. (12)
Antioxidant Screening / Antibacterial: Antioxidant screening of an aqueous extract
yielded enzymatic antioxidants such as catalase, superoxide dismutase,
ascorbate oxidase and non-enzymatic antioxidant ascorbic acid. The extract
exhibited antibacterial activity against S. aureus, E. coli and P.
Antifungal / Antibacterial: A crude ethanolic extract exhibited antibacterial
and antifungal activities against Staphylococcus aureus and Candida albicans. (14)
Antineoplastic / Stem Bark: Study evaluated the antineoplastic activity of a
total methanolic extract of stem bark of K. pinnata. TME evoked DNA laddering
in SKW-3 cells indicating apoptosis induction. In vitro and in
vivo studies displayed prominent cytotoxicity against human tumor cell
Antiurolithic Activity: Study evaluated an ethanolic extract of fruit of
Kigelia pinnata on calcium oxalate urolithiasis in male Wistar albino rats
induced by ethylene glycol feeding. Results showed antiurolithic activity with
significantly reduction of elevated urinary oxalate, uric acid and phosphate,
with decrease deposition of stone forming constituents in the kidneys of
calculogenic rats. (16)
Anti-Inflammatory: Study evaluated the anti-inflammatory activity of
a leaf extract of Kigelia pinnata on wistar rats by carrageenan-induced paw
edema and cotton pellet-induced granuloma methods. Results showed
dose-dependent anti-inflammatory effects. (17)
Wound Healing: Study evaluated the wound healing potential of an aqueous extract
of shade-dried bark in rats, using incision, excision, and dead space wound
models. Results showed wound healing efficacy which was attributed to
Analgesic: Study on wistar rats evaluated a leaf
extract of K. pinnata for analgesic activity. Results showed significant
analgesic activity by hot plate and tail flick methods. (19)
Antidiabetic / Hypolipidemic / Flowers: Study evaluated the antidiabetic and
hypolipidemic activities of methanolic flower extracts in
streptozotocin-induced diabetic wistar rats. Results showed significant
reduction of blood glucose, serum cholesterol and triglyceride levels. (20)
Analgesic / Cytotoxic Activity/ Flowers: Study evaluated various extracts of four
medicinal plants for analgesic and cytotoxic activities by acetic acid-induced
writhing and brine shrimp lethality assay. The bark of K. pinnata showed
significant analgesic and cytotoxic activity and may have a potential in the
treatment of pain and tumor. (21)
Antimicrobial / Cytotoxic Activity/ Flowers: Study of leaf, stem bark and root extracts
of K. africana and S. hispidus showed antimicrobial, antioxidant, and enhanced
wound healing properties and may justify its medicinal use for the treatment of
microbial infections and wounds. (22)
Anti-Inflammatory / Fruit: A methanolic
extract of fruit was studied in various in vivo models of inflammation in rats
and mice. Result showed dose-dependent and significant inhibition in all
experimental models comparable to standard drugs. Acute toxicity study showed
no mortality in dose up to 2000 mg/kg p.o. (23)
Antiamoebic Activity / Iridoids: Study evaluated the antiamoebic activity of
iridoids isolated from K. pinnata stem bark butanol extract. Three known
iridoids were isolated, viz., specioside, verminoside, and minecoside and
tested against HK-9 strain of Entamoeba histolytica. Verminoside showed two-fold
antiamoebic activity compared to standard drug. Specioside showed
comparable activity with metronidazole. (24)
Anti-Melanoma / Cytotoxicity / Fruits: Study evaluated components of fruits of K.
pinnata with potential growth inhibitory activity against human melanoma cells.
Crude fractions showed cytotoxicity in vitro against human melanoma cells.
Compounds isolated included isocoumarins, (demethylkigelin and kigelin), fatty
acids (oleic and heneicosanoic acids), the furonaphthoquinone,
2-(1-hydroxyethyl)-naphtho[2,3-b]furan-4,9-dione, and ferulic acid. The
furonaphthoquinones showed cytotoxic effect in two human breast cancer cell
lines tested. (25)
DISCLAIMER: Make sure you do NOT have any allergies to the product by testing a small area on your skin first. Pregnant women or people being treated for skin or hair problems should consult with a physician before using. This product is not intended to diagnose, treat, cure or prevent any disease. Results may vary. Kigelia is not FDA approved.